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'Avengers' Smashes Box-Office Records: Experts Weigh In

'We are really in uncharted territory now with an opening like this,' one box-office expert tells MTV News.
By Fallon Prinzivalli


Scarlett Johansson in "The Avengers"
Photo: Disney/ Marvel

It's safe to say that everyone expected Marvel's "The Avengers" to smash the box office when it opened in U.S. theaters this weekend, but no one could foresee just how many records it would break.

According to Deadline Hollywood, the Joss Whedon-directed film grossed more than $207 million domestically this weekend, blasting away the "Harry Potter and the Deathly Hallows, Part 2" record of $169 million. The film now also holds the #1 spot for highest Saturday gross of all time with a whopping $69.7 million made in a single day.

"We are really in uncharted territory now with an opening like this," Phil Contrino of BoxOffice.com told MTV News.

With "Avengers" exceeding fan and critic expectations, is the film poised to break any other records? Box Office Guru editor Gitesh Pandya predicts some hefty numbers. "It also broke the speed record for hitting $200 million, doing it in a mere three days, beating a trio of past hits that did it in five days," he said. "And I project it will become the fastest film in history to smash the $1 billion global box-office mark, doing it in about 20 days or so. 'Avengers' just might end up becoming the highest-grossing non-James Cameron film ever."

Exhibitor Relations' Jeff Bock agrees, saying, "[It] will likely take down many of 'The Dark Knight' and 'Deathly Hallows, Part 2' [records], including best first-week gross and fastest to $300 million."

But with such huge numbers in the beginning, there's a chance the film could drastically drop in weeks to come. "I don't think it can possibly manage to drop only 55-60 percent like most summer blockbusters, but if it does then it could very well challenge the $533.3 million domestic gross of 'The Dark Knight,' " Contrino said. "I don't think it will catch 'Titanic' or 'Avatar' domestically, but I wouldn't completely rule it out either. It all depends on how much repeat business it gets."

Pandya agrees that "Avengers" will have a sizable drop in its second weekend in theaters. "We won't see 'Titanic' or 'Avatar'-type legs here, but a final domestic gross of more than $450 million seems likely."

Bock is a little more optimistic, putting the overall domestic tally at $500 million. "As reviews have been through the roof, it will definitely benefit from repeat viewings," he said. " 'The Avengers' success is now the model by which all comic book franchises will now be judged. This certainly played out like a sequel, because it was built like one. In fact, this was a super-sequel arriving with the most built-in buzz in the history of modern-day cinema."

Contrino credits the buzz to Disney's incredible campaign to market the film. "They combined traditional marketing — TV spots, trailers — with plenty of outreach on Facebook and Twitter. Marketers will be studying this for years to come."

But marketing departments won't be the only teams studying up on Disney and Marvel's success. Bock believes DC Comics should be taking some notes. "Marvel maneuvered their characters like Bobby Fischer moved chess pieces — always thinking of the next move," he said.

"This was Marvel's master plan from the beginning and it turned into a master class. If DC can eventually get all their universe straightened out, there is no reason a Justice League movie couldn't blow up the box office like Marvel's 'Avengers' did."

Pandya agrees, crediting the success in part to the directors. "Other studios should learn to trust big franchises in the hands of talented directors and to keep fans engaged throughout the process so they feel like they are part of the team," he said. "Give audiences a solid piece of entertainment and they will reward you back with huge bags of cash."

Check out everything we've got on "The Avengers."

For breaking news and previews of the latest comic book movies — updated around the clock — visit SplashPage.MTV.com.

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Scientists aim to kill lung tumors

Saturday, May 5, 2012

Lung cancer is the leading cause of cancer death throughout the world. Standard treatment methods do not usually result in long-term recovery. In addition to the proliferation of the tumour cells, the growth of blood vessels controls tumors development. The blood vessel growth is controlled by several signalling molecules. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim and Justus Liebig University Giessen have discovered a molecule that plays a key role in this process. They succeeded in reducing tumour growth in their experiments by blocking the phosphodiesterase PDE4.

Lung cancer mainly affects smokers; however the disease can also be caused by contact with carcinogenic substances like asbestos. Chemotherapy or radiotherapy often prove insufficient in treating the disease. Hence, scientists are engaged in an intensive search for ways of halting the growth of lung tumours. The blood vessels that supply the tumour with nutrients offer a potential point of attack.

New blood vessels form to ensure an adequate supply of nutrients to the growing tumour. The growing tissue is immediately penetrated by blood vessels. The growth of the blood vessels is regulated by the tumour cells using a complex signal cascade, which is triggered initially by a low oxygen content (hypoxia) in the tumour tissue. "This state, which is known as hypoxia prompts the activation of around 100 genes in the tumour cells," explains Rajkumar Savai, research group leader at the Max Planck institute. "In addition to the growth of blood vessels, hypoxia also stimulates the proliferation of lung cancer cells." Three molecules play a particularly important role in this process. The activation of the genes at the beginning of the cascade is triggered by the transcription factor HIF and a messenger molecule, cAMP, is involved again at the end of the cascade. The researchers examined the third molecule that acts as a link between these two molecules in detail.

The molecule in question is a phosphodiesterase, PDE4. The scientists from Bad Nauheim and Giessen were able to demonstrate in their study that various sections of PDE4 have binding sites for HIF.

The researchers then tested the influence of a PDE4 blockade on the cells from ten different cell lines, which are characteristic of around 80 percent of lung cancers, in the laboratory. The rate of cell division in the cells treated with a PDE4 inhibitor was significantly lower and the HIF level also declined as a result.

The effect in the tumour bearing mice was particularly obvious. To observe this, the Max Planck researchers implanted a human tumour cell line under the skin of nude mice and treated the animals with the phosphodiesterase 4 inhibitor.

Tumour growth in these animals declined by around 50 percent. "Our microscopic analysis revealed that the blood vessel growth in the tumours of the mice that had been treated with the inhibitor was significantly reduced. We also observed indicators of decelerated cell division in the tumour cells. Overall, the tumour growth was strongly curbed."

Werner Seeger, Director of the MPI and Medical Director of the JLU University Hospital Giessen, reports: "We were able to show that PDE4 plays an important regulation function in cell division in lung tumours and in the development of blood vessels in cancer. Therefore, we hope that we have found a starting point for the development of a treatment here." In the view of tumour specialist Friedrich Grimminger, Chairman of the Department of Medical Oncology in Giessen, it may be possible in future to combine the inhibition of PDE4 with traditional radiotherapy or chemotherapy. In this way, the effect of the traditional treatment measures could be reinforced and patient prognoses may improve as a result. However, further laboratory studies are required before clinical tests can be carried out.

###

Original publication: S. Pullamsetti, G. Banat, A. Schmall, M. Szibor, D. Pomagruk, J. H?nze, E. Kolosionek, J. Wilhelm, T. Braun, F. Grimminger, W. Seeger, R. Schermuly, R. Savai: Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF. Oncogene (2012). doi:10.1038/onc.2012.136

Max-Planck-Gesellschaft: http://www.mpg.de

Thanks to Max-Planck-Gesellschaft for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Essential News from The Associated Press

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US airstrike kills senior al-Qaida leader in Yemen

SANAA, Yemen (AP) ? An airstrike Sunday killed a top al-Qaida leader on the FBI's most wanted list for his role in the 2000 bombing of the USS Cole warship, Yemeni officials said. The drone attack was carried out by the CIA, U.S. officials said.

Fahd al-Quso was hit by a missile as he stepped out of his vehicle, along with another al-Qaida operative in the southern Shabwa province, Yemeni military officials said. They were speaking on condition of anonymity in accordance with military regulations.

The drone strike that killed Quso was carried out by the CIA, after an extended surveillance operation by the CIA and U.S. military, two U.S. officials said. They spoke on condition of anonymity because they were not authorized to speak to the media.

The strike was authorized by the Yemeni government, which then made the announcement after the operation was complete, the officials said, part of the U.S. strategy to give the host government more public ownership of the operation being carried out on Yemeni soil.

The airstrike came as the U.S. and Yemen cooperate in a battle against al-Qaida in southern Yemen.

Al-Quso, 37, was on the FBI's most wanted list, with a $5 million reward for information leading to his capture. He was indicted in the U.S. for his role in the 2000 bombing of the USS Cole in the harbor of Aden, Yemen, in which 17 American sailors were killed and 39 injured.

He served more than five years in a Yemeni prison for his role in the attack and was released in 2007. He briefly escaped prison in 2003 but later turned himself in to serve the rest of his sentence.

A telephone text message claiming to be from al-Qaida's media arm confirmed al-Quso was killed in the strike.

Al-Quso was also one of the most senior al-Qaida leaders publicly linked to the 2009 Christmas airliner attack. He allegedly met with the suspected Nigerian bomber, Umar Farouk Abdulmutallab, in Yemen before he left on his way to execute his failed attack over Detroit with a bomb concealed in his underwear.

In December 2010, al-Quso was designated a global terrorist by the State Department, an indication that his role in al-Qaida's Yemen offshoot, al-Qaida in the Arabian Peninsula, had grown more prominent.

Local Yemeni official Abu Bakr bin Farid and the Yemeni Embassy in Washington confirmed al-Quso was killed in Rafd, a remote mountain valley in Shabwa. It is the area where many al-Qaida leaders are believed to have taken cover, including the U.S.-born cleric Anwar al-Awlaki, who was killed in a U.S. airstrike in Yemen last year.

Yemeni government officials reported that al-Quso and al-Awlaki were killed in an airstrike in 2009 in Rafd, but they both resurfaced alive.

Al-Quso was known for his ability to move in disguise. He was from the same tribe as al-Awlaki, and local tribesmen said he was a close aide. He studied ultraconservative Salafi Islam as a teenager in northern Yemen, then returned home to learn welding.

The White House and the State Department had no immediate comment.

Yemen's government has been waging an offensive on al-Qaida militants, who have taken advantage of the country's political turmoil over the last year to expand their hold in the south.

The new Yemeni president has promised improved cooperation with the U.S. to combat the militants. On Saturday, he said the fight against al-Qaida is in its early stages.

Al-Quso's association with al-Qaida dated back more than a decade, when he met with Osama bin Laden in Afghanistan. Bin Laden allegedly told him to "eliminate the infidels from the Arabian Peninsula."

From there he rose through the ranks. He was assigned in Aden to videotape the 1998 suicide bombing of the USS Cole, but he fell asleep.

Despite the lapse, the local leader, Nasser al-Wahishi, declared him the regional leader in Aden. He was also believed to have played a prominent role in al-Qaida's attack and capture last year of Zinjibar, the capital of Abyan province.

Government troops are trying to drive al-Qaida out of Zinjibar.

____

AP Intelligence Writer Kimberly Dozier in Washington contributed to this report.

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Grooming pets is actually less in relation to appearance and much ...

Pet grooming Most dogs is a lot more than only of an appealing dog. Proper grooming is really a numerous split hobby affecting several elements of training dogs. It offers significant associations for that health, personal hygiene plus health of one?s dog.

The first thing you should do is decide the goal of pet grooming. Are you proper grooming your pet intended for common overall look in addition to tidiness or even think you?re proper grooming them for a skilled dog display. Grooming represents an alternative contour when it?s important for the actual function of featuring as in the truth connected with demonstrate pets.

If you find a functionality or maybe competitors engaged, the quality of looking after gets to be extremely thorough using close up care about every tiny facet of look and feel. In such a scenario you could perhaps need to get the animal to some professional pet groomer for a few of the brushing wants.

Simple projects throughout proper grooming pet dogs at home:
- bathing
- brushing fur along with taking good care of the cover
- cleaning plus blow drying eardrums
- clipping claws
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- cutting or perhaps cutting down on coat
- cleaning pearly white?s

You should not moan, it is usually enjoyment: Looking after is actually a chore, no doubt this. The project with grooming puppies usually solicits your cringe by owners plus they tend to procrastinate as it is often frustrating. Community . is just not a straightforward workout, you will find there?s smarter facet once you lick your canine friend on your own.

You can see your canine friend, bond with it in addition to kind a 60 minute during one interconnection. When you finally have involved with it with your process, you may essentially start enjoying the time frame invested with all your dog. At the conclusion of it you do have a wonderful sensing, neat and delighted canine.

How much does grooming involve for you:
o Time
You must hold to one side a few hours or even spread different self care needs of the animal over a few days

o Effort
Coping with huge serious pet dog similar to an Older is a little of any concern though washing in addition to pet grooming. There could also be quite a few ability to resist having.

Gold Retrievers try to be within the water and they love skating however they may not screen the same excitement while in tub situations. You might need to encourage your pet as well as prepare this to buy the actual vacant container 1st. Employ tiny food items sweets to compensate compliance. When your pet is comfortable, then you can certainly perform a bath.

o Meticulousness
If you want to perform a best career, then you need to become detailed plus proceed through all of the minutest pet grooming desires of this furry friend, as well as gazing to the head of the family pet to see if they can be dry and clean.

o Consistency
As individuals need a normal shower, must clip claws routinely, need to toned their head of hair or obtain a haircut, really need to clean up their particular eardrums, and require to help keep the head of hair shampooed along with cleanse, this sort of pet grooming needs happen in the animal likewise. Since it cannot do some of these without attention, it will become your own responsibility.

The particular brushing visits should go a long way inside creating trust in addition to nearness in between mom and her dog.

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The most, and least safe states in America

AP

Violent crime weighs heavily on the economy. Financial burdens include static costs, such as medical judicial costs, as well as dynamic costs, such as lost productivity arising from injuries and incarceration.

By Charles B. Stockdale and Michael B. Sauter, 24/7 Wall St.

The United States is more peaceful now than at any time in the past 20 years. Nevertheless, violence still cost the economy at least $460 billion in 2010, through a combination of lost productivity and direct costs, according to a new report published by the Institute for Economics and Peace. 24/7 Wall St. analyzed the report in order to identify the most and least peaceful states, as well as how much they spend on violence.

Louisiana, which is the least peaceful state, has the highest rate of homicide. Maine is the most peaceful state and has the lowest rate of violent crime.

Peace, according to the Institute for Economics and Peace,?is a combination of the absence of violence and the institutions required to address it. In an interview with 24/7 Wall St., chairman and founder of the IEP, Steve Killelea explained, ?In perfect states, there?d be no crime, therefore you?d have no need for police, nor would you lock anyone up.?

The report considers five categories -- separated into three groups -- to calculate the United States Peace Index for 2011. The first group includes rates of violent crimes such as robbery and aggravated assault, as well as the rates of homicide in each state. The second group relates to the institutions used to prevent violence and is measured by the number of police per capita and the number of incarcerated residents per capita. The third includes the availability of small arms.

Violent crime weighs heavily on the economy. Financial burdens include static costs, such as medical judicial costs, as well as dynamic costs, such as lost productivity arising from injuries and incarceration. Medical costs resulting from assault cost the U.S. nearly $38 billion in 2010. Costs arising from homicides totaled more than $91 million.

While the causes of violence are not made clear, IEP?s analysis suggests a relationship between socioeconomic factors and violence. ?I don?t think there?s a single silver bullet which creates peace,? Killelea told 24/7. ?I think it?s multi-dimensional and really complex. So, on that basis, we?ve pulled out the correlations.? Rather than finding the causes, Killelea explained, the IEP tried to identify environments that suggest high violence.

To do this, the Institute for Economics and Peace considered 42 additional sets of data in five categories -- education, health, economic opportunity, civics and demographics, community and social capital -- to identify factors that may cause, be caused by or correlated with violence and high levels of enforcement.

24/7 Wall St.: America's most miserable states

After examining these data sets, 24/7 Wall St. identified 17 factors that were highly correlated with the measures of peace, although it is unclear as to the causal relationship between the two -- if any. Of those 17 factors, we considered 10 that appeared to be the most directly related to the presence of violence and the methods states use to maintain law and order.

In the category of economics, absolute poverty rates appear to be correlated with violent conditions. Nine of the 10 most peaceful states were among the 20 with the lowest poverty rates. On the other hand, six of the 10 least peaceful were among the 10 poorest states.

A number of education-related metrics correlate strongly with how peaceful the states are. According to Killelea, ?it is not so much the quality of education that matters for peace, but that states keep children in school and off the streets.?

The strongest correlation with peace among the education data is the share of a state?s population with at least a high school diploma. In Texas, which is among the least peaceful states, just over 80 percent have at least a high school diploma -- the country?s lowest rate. Minnesota?s rate of nearly 92 percent is the country?s second highest. That state is also one of the most peaceful.

24/7 Wall St. used the Institute for Economics and Peace?s second annual study, The United States Peace Index, to identify the 10 most and least peaceful states in the country. The level of peacefulness in each state was based on five weighted metrics, including violent crime, homicide, the presence of police officers and the number of incarcerations per capita. The least-weighted of these was the availability of small arms.

Using IEP?s original sources, 24/7 Wall St. reproduced state data for 10 of the factors the report determined to have the strongest correlations nationally to the five measures of peace. These were teenage birth rates, teenage death rates, life expectancy at birth, percentage of people without health insurance, percentage of people with at least a high school degree, labor force participation, basic access to things needed for well-being, percentage of children in single parent families, poverty rate and income inequality -- measured by the Gini coefficient.

America?s most peaceful states?

1. Maine

  • Violent crimes (excluding murder) per 100,000: 120.2 (the least)
  • Murders per 100,000: 1.8 (tied for seventh least)
  • Incarceration rate per 100,000: 148 (the least)
  • Police per 100,000: 213.9 (the least)
  • Basic access: 84.0 (16th highest)
  • Total cost of violence: $801 million

Maine is the most peaceful state in the country, as it has been since 2000. The state has the lowest rate of violent crime excluding murder. It averages 120 violent crimes per 100,000, while Nevada, the state with the most crimes, averages 654. It also has the lowest incarceration rate, effectively eight times lower than Louisiana?s, or the least peaceful state. In addition, Maine has the lowest rate of police employees among its population -- over half that of New Jersey.

24/7 Wall St.: America's most corrupt states

2. Vermont

  • Violent crimes (excluding murder) per 100,000: 129.1 (second least)
  • Murders per 100,000: 1.1 (second least)
  • Incarceration rate per 100,000: 265 (ninth least)
  • Police per 100,000: 414.8 (fourth most)
  • Basic access: 84.1 (15th highest)
  • Total cost of violence: $447 million

Vermont is one of the most peaceful states in the country, with just 129.1 violent crimes and 1.1 murders per 100,000 people. The state is near the top for nearly every major indicator that the Peace Project has identified as being correlated with a low rate of violence and a high level of peace. The Green Mountain State is among the top 10 in the country for graduation rates, labor participation, and health insurance coverage. It also has the third-lowest rate of teen births in the country at 21.3 percent.

3. New Hampshire

  • Violent crimes (excluding murder) per 100,000: 166.0 (third least)
  • Murders per 100,000: 1.0 (the least)
  • Incarceration rate per 100,000: 209 (fifth least)
  • Police per 100,000: 288.6 (16th least)
  • Basic access: 85.4 (fifth highest)
  • Total cost of violence: $952 million

New Hampshire?s high level of peace may be the result of its sound economic conditions. Only 8.1 percent of state residents are living in poverty -- the lowest rate in the country. It also has one of the lowest rates of income inequality. Additionally, New Hampshire has the lowest rate of homicide in the country, the third-lowest rate of other violent crimes and the fifth-lowest incarceration rate. New Hampshire also has a 91.5 percent high school graduation rate -- the fourth-highest -- and the lowest rate of births among teenagers.

Read the rest of America's most peaceful states at the 24/7 Wall St. website.

America?s least peaceful states

1. Louisiana

  • Violent crimes (excluding murder) per 100,000: 537.8 (eighth most)
  • Murders per 100,000: 11.2 (the most)
  • Incarceration rate per 100,000: 867 (the most)
  • Police per 100,000: 542.8 (the most)
  • Basic access: 79.2 (fifth lowest)
  • Total cost of violence: $9.82 billion

Of the five metrics used to generate the Peace Index, Louisiana received the absolute worst score in all but two of them. The state has the eighth-worst violent crime rate and the fourth-worst rate of gun suicides. The state has the highest levels of both police per capita and incarceration. The state?s 867 prisoners per 100,000 people is well more than the next-worst state, Mississippi, which has 686 prisoners per 100,000. The state?s murder rate is what truly sets it apart as the least peaceful in the country. Louisiana?s homicide rate in 2010 was 11.2 per 100,000 residents. The next-worst state, Maryland, had 7.4 murders per 100,000 people. Louisiana was also among the worst 10 states for each of the 10 categories shown to have a high level of correlation with violence.

2. Tennessee

  • Violent crimes (excluding murder) per 100,000: 607.7 (fourth most)
  • Murders per 100,000: 5.6 (12th most)
  • Incarceration rate per 100,000: 432 (22nd most)
  • Police per 100,000: 404.8 (sixth most)
  • Basic access: 81.0 (17th lowest)
  • Total cost of violence: $11.67 billion

Tennessee is the second-least peaceful state in the country, and has in fact gotten worse since 1991. Additionally, the Nashville-Davidson-Murfreesboro-Franklin metropolitan area is among the worst metro areas for peace. The state is one of the most violent, with nearly 608 violent crimes committed per 100,000 residents in 2010. The state also has among the largest relative number of police employees -- nearly 405 per 100,000 people. Tennessee also has one of the largest rates of children living in single parent households, one of the highest poverty rates, one of the lowest rates of income inequality and one of the highest rates of births among teenagers.

3. Nevada

  • Violent crimes (excluding murder) per 100,000: 654.7 (the most)
  • Murders per 100,000: 5.9 (eighth most)
  • Incarceration rate per 100,000: 472 (13th most)
  • Police per 100,000: 365.6 (13th most)
  • Basic access: 78.0 (second lowest)
  • Total cost of violence: $5.47 billion

Many of the factors that normally correspond with a high rate of violence are not present in Nevada. The state is actually in the top 50 percent for poverty rate, income equality, and labor force participation. On the other hand, the state has a high teen birth rate and the second-highest percentage of its population without health insurance. Its citizens also have, according to Gallup, the second-worst access to basic necessities in the country. The state has the highest violent crime rate in the country, with 654.7 per every 100,000 residents recorded in 2010.

Read the rest of America's least peaceful states at the 24/7 Wall St. website.

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'This Week' Extra: Roundtable Post-Show Thoughts

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